| 科研成果： |
PUBLICATIONS 1. Zhu R, Lu L, Zhu M, Han H, Yuan C, Xing S*, Fu X. Synthesis and evaluation of copper complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatases. Inorg Chim Acta. 2013, 405: 91-97. 2. Wu Q, Wang S, Ma J, Li W, Xing S*, Fu X. Rapid Screening of 3-Hydroxy-3-methylglutaryl CoA Reductase Inhibitors by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry. Chinese J Anal Chem. 2013, 41: 1013-1018 3. Han H, Lu L, Wang Q, Zhu M, Yuan C, Xing S*, Fu X. Synthesis and evaluation of xovanadium (iv) complexes of Schiff-base condensates from 5-substituted-2-hydroxy benzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B. Dalton Trans. 2012, 41: 11116-11124. 4. Lu L, Gao X, Zhu M, Wang S, Wu Q, Xing S*, Fu X, Liu Z, Guo M. Exploration of biguanido-oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases. Biometals. 2012, 25(3): 599-610. 5. Wang Q, Zhu M, Zhu R, Lu L, Yuan C, Xing S, Fu X, Mei Y, Hang Q. Exploration of α-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases. Eur J Med Chem. 2012, 49: 354-364. 6. Yuan C, Zhu M, Wang Q, Lu L, Xing S, Fu X, Jiang Z, Zhang S, Li Z, Li Z, Zhu R, Ma L, Xu L. Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(ii) complex. Chem Commun (Camb). 2012, 48(8):1153-5. 7. Wang Q, Zhu M, Lu L, Yuan C, Xing S, Fu X. Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization and biological activities. Dalton Trans. 2011, 40(48): 12926-34. 8. Li Y, Lu L, Zhu M, Wang Q, Yuan C, Xing S, Fu X, Mei Y. Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives. Biometals. 2011, 24(6): 993-1004. 9. Ma L, Lu L, Zhu M, Wang Q, Gao F, Yuan C, Wu Y, Xing S, Fu X, Mei Y, Gao X. Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases. J Inorg Biochem. 2011, 105(9):1138-1147. 10. Ma L, Lu L, Zhu M, Wang Q, Li Y, Xing S, Fu X, Gao Z, Dong Y. Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases. Dalton Trans. 2011, 40(24): 6532-6540. 11. Ma J, Li Z, Xing S, Ho WT, Fu X, Zhao ZJ. Tea contains potent inhibitors of tyrosine phosphatase PTP1B. Biochem Biophys Res Commun. 2011, 407(1): 98-102. 12. Zhao W, Gao R, Lee J, Xing S, Ho WT, Fu X, Li S, Zhao ZJ. Relevance of JAK2V617F positivity to hematological diseases--survey of samples from a clinical genetics laboratory. J Hematol Oncol. 2011, 4: 4. 13. Yuan C, Lu L, Wu Y, Liu Z, Guo M, Xing S, Fu X, Zhu M. Synthesis, characterization, and protein tyrosine phosphatases inhibition activities of oxovanadium(IV) complexes with Schiff base and polypyridyl derivatives. J Inorg Biochem. 2010, 104(9): 978-986. 14. Lu L, Wang S, Zhu M, Liu Z, Guo M, Xing S, Fu X. Inhibition protein tyrosine phosphatases by an oxovanadium glutamate complex, Na(2)[VO(Glu) (2)(CH (3)OH)](Glu = glutamate). Biometals. 2010, 23(6):1139-1147. 15. Zhang X, Xing S, Wu X, Lin F, Fu X, Li W. Purification and characterization of protein tyrosine phosphatase MEG1 and preparation of anti-PTPMEG1 antibody. Chem Res Chinese U. 2010, 26(4): 591-595 16. Xing S, Ho WT, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ. Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008, 111(10): 5109-5117. 17. Li Z, Xing S, Wang S, Ho WT, Zhao ZJ. Characterization of a highly effective protein substrate for analysis of JAK2 (V617F) activity. Exp Hematol., 2007 Nov; 35(11): 1624-32. 18. Li Z, Xu M, Xing S, Ho WT, Ishii T, Li Q, Fu X, Zhao ZJ. Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth. J Biol Chem. 2007, 282(6): 3428-3432. 19. Xu X, Zhang Q, Luo J, Xing S, Li Q, Krantz SB, Fu X, Zhao ZJ. JAK2(V617F): prevalence in a large Chinese hospital population. Blood. 2007, 109(1): 339-342. 20. Zhao R, Xing S, Li Z, Fu X, Li Q, Krantz SB, Zhao ZJ. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. 2005, 280(24): 22788-22792. MEETING ABSTRACTS 1. Wanming Zhao, Shu Xing, Rufei Gao, Aref Al-Kali, Wanting Tina Ho and Zhizhuang Joe Zhao. Generation and Characterization of Transgenic Mice Expressing MplW515L. Poster Session. The 51st ASH annual meeting, 2009, New Orleans, LA, USA. 2. Shu Xing, Wanming Zhao, Wanting Tina Ho and Zhizhuang Joe Zhao. Transgenic Expression of Wild Type JAK2 Suppresses Myeloproliferative Disorder Phenotypes Induced by Mutant JAK2V617F in Mice. Oral Session. The 50th ASH annual meeting, 2008, San Francisco, CA, USA. 3. Shu Xing and Zhizhuang Joe Zhao. Transgenic Expression of JAK2V617F Causes Myeloproliferative Disorders in Mice. Poster Session. The 49th ASH annual meeting, 2007, Atlanta, GA, USA. |
