一、主持科研项目(课题)及人才计划项目情况 1. 2020年度国家高层次青年人才,2021年4月; 2. 吉林省“双十工程”重大科技成果转化项目(子课题负责人),20130201006ZY,2013.12-2015.12,60万元,结题; 3. 吉林省“双十工程”重大科技成果转化项目(子课题负责人),20140301003YY,2014.1-2016.12,40万元; 4. 吉林省重大科技攻关招标项目(项目负责人),20150203002NY,2015.1-2017.12,75万元,结题 5. 国家青年自然科学基金,81402955,2015.1-2017.12,23万元,结题; 6. 国家重点研发计划(“科技助力经济2020”国家重点专项)(子课题负责人),,2020YFF0414043,2020.07-2021.12,15万元,结题; 7. 吉林省科技发展计划(吉林省医药健康专项)(子课题负责人), 20191102027YY, 2019.1-2021.12,27万元,结题; 8. 国家重点研发计划(政府间国际科技创新合作重点专项)(子课题负责人),,2018YFE0107800,2019.7-2022.12,50万元,在研; 9. 专利转让,通化仁生源科技有限公司,201622002000186,2016.10-2035.10,150万元; 10. 专利转让,,北京中京丰创科技有限公司,2019220002000365,2019.11-2038.11, 80.0万元; 二、代表学术论文 1. Chunyue Wang, Shanshan Chen, Hangyu Guo, Hongbo Jiang, Honghan Liu, Haoran Fu, Di Wang, Forsythoside A Mitigates Alzheimer’s-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation. International Journal of Biological Sciences, 2022, 18(5):2075-2090. (IF:6.58) 2. Wenji Hu#, Minkai Song, Chunyue Wang, Di Wang* Pharmacological Basis for Application of Polysaccharide Purified from Amanita caesarea in Alzheimer's Disease: Oxidative Stress and Endoplasmic Reticulum Stress, International Journal of Biological Macromolecules, 2021, 193:358-369(IF: 6.953) 3. Shimiao Wang#, Yuchong Zhang #, Weiqi Meng, Lesheng Teng, Yang Liu, Lanzhou Li*, Di Wang*, The Involvement of Macrophage Colony Stimulating Factor on Protein Hydrolysate Injection Mediated Hematopoietic Function Improvement, Cells, 2021, 10, 2776. (IF:6.6) 4. Wenji Hu#, Zhiping Li#, Wenqi Wang, Ruitao Dong, Di Wang* Structural characterization of polysaccharide purified from Amanita caesarea and its Pharmacological Basis for Application Alzheimer's Disease: Oxidative Stress and Endoplasmic Reticulum Stress Food & Function, 2021,12: 11009-11023. DOI: 10.1039/d1fo01963e (IF: 5.1) 5. Wenqi Wang#, Hor-Yue Tan#, Shanshan Chen#, Zhiping Li, Yuanjun Lu, Di Wang * and Ning Wang * Role of autophagy in the maintenance of stemness: a disease-relevant mechanism of action, Frontiers in Cell and Developmental Biology. 2021: 715200 (IF: 6.648) 6. Yaqin Zhang, Minyan Chen, Chengrong Liu, Jiaqi Chen, Xinyi Luo, Yingying Xue, Qiming Liang, Li Zhou, Yu Tao, Mingqiang Li, Di Wang*, Jianhua Zhou1, Jiasi Wang*,Sensitive and Rapid On-Site Detection of SARS-CoV-2 Using a Gold Nanoparticle Based High-throughput platform Coupled with CRISPR/Cas12-assisted RT-LAMP, Sensors and Actuators B:Chemical, 2021, 345: 130411 (IF:7.46) 7. Dongjie Li#, Qiubo Chu#, Shimiao Wang#, Lanzhou Li, Bo Dou, Jiawei He, Yaping Tian*, Di Wang*. ZhenQi FuZheng granules improve mouse hematopoietic function after cyclophosphamide-induced damage via enhancing M-CSF levels through Nrf2 and NF-κB signaling. 2020, Clinical and Translational Medicine. 2020, 10, e256. (IF: 11.492) 8. Chunyue Wang#, Xueying Cai#, Siyu Zhai, Yongfeng Zhang, Wenji Hu, Yizhi Zhang*, Di Wang* Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice. Journal of Neuroinflammation 2020, 17: 309 (IF: 8.322)(1区) 9. Fan’ge Kong#, Xue Jiang#, Ruochen Wang, Siyu Zhai, Yizhi Zhang*, Di Wang* Forsythoside B attenuates memory impairment and neuroinflammation via inhibition of NF-κB signaling in Alzheimer’s disease. Journal of Neuroinflammation. 2020,17: 305 (IF:8.322) 10. Lanzhou Li, Xue Jiang, Shanshan Teng, Luping Zhang, Lesheng Teng*, Di Wang* Calf Thymus Polypeptide Improved Hematopoiesis via regulating colony-stimulating factors in BALB/c mice with hematopoietic dysfunction. International Journal of Biological Macromolecules, 2020, 156:204-216 (IF: 6.953) 11. Yidi Qu, Hor-Yue Tan, Yau-Tuen Chan, Hongbo Jiang, Ning Wang*, Di Wang*, The functional role of long noncoding RNA in resistance to anticancer treatment, 2020, Therapeutic Advances in Medical Oncology, 2020, 12:1-18 (IF: 8.168) 12. Yidi Qu, Bo Dou, Hor Yue Tan, Yibin Feng*, Ning Wang* Di Wang*, Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment, Molecular Cancer, 2019, 16:69 (IF: 15.302) 13. Xue Wang, Qiubo Chu, Xue Jiang, Yue Yu, Libian Wang, Yaqi Cui, Jiahui Lu, Lirong Teng*, Di Wang* Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway, Cell Death & Disease, 2018, 21;9(6):578. (IF: 5.959) 三、代表专利 (1)一种具有神经保护作用的化合物及医用用途 (ZL201510674867.X) 授权公告日:20170111 发明人:王迪; 胡爽; 张峻榕; 寮渭巍; 邹恭峰; 刘春刚; 杜梦妍; 张宁; 李秋月。 (2)一种定向合成化合物CLCN及其在抗肝癌药物中的应用(ZL201510320072.9) 授权公告日:20170825 发明人:王迪,逯家辉,周毓麟,王迪,孟庆繁,滕利荣,张洋,孟令军,权宇彤,姜丹 (3)白囊耙齿菌在制备耐缺氧药物中的用途(ZL201410328592.X) 授权公告日:20171024 发明人:王迪,李臣亮,滕利荣,孟庆繁,宋佳,逯家辉,刘艳,王贞佐,周毓麟,刘春刚,程英琨,权宇彤; (4)绣球菌多糖提取物在制备治疗神经退行性疾病药物的用途 (ZL201510285844.X) 授权公告日:20171124 发明人:王迪,胡爽,张峻榕,曾浩,权宇彤,逯家辉,闫国栋,滕利荣 (5)一种牛樟芝诱变菌株及培育方法 (ZL201510294438.X) 授权公告日:20180511 发明人:王迪,刘燕隔,王娟,孟庆繁,刘艳,袁莉莎,滕利荣,逯家辉,权宇彤 (6)一种高产安络小皮伞诱变菌株及培育方法 (ZL201510183449.0) 授权公告日:20180522 发明人:王迪,宋佳,王贞佐,曹家铭,孟庆繁,滕利荣,蔡广胜,逯家辉,权宇彤 (7)蝙蝠蛾拟青霉菌株PH40在抗抑郁症中的医用用途 (ZL201510281896.X) 授权公告日: 20180612 发明人:王迪,王娟,刘艳,滕利荣,刘洋,程瑛琨,权宇彤,周毓麟,逯家辉 (8)一种高产松茸诱变菌株及培育方法(ZL201510281406.6) 授权公告日: 20180814 发明人:王迪,李佺,孟庆繁,王迪,王美羽,滕利荣,逯家辉,黄晨玮,张洋,权宇彤 (9)一种羊肚菌和牛肝菌复方粗多糖及制备方法和医用用途(ZL201810999115.4) 授权公告日: 20210105 发明人:王迪,逯家辉, 刘燕隔, 滕利荣, 孟庆繁, 周毓麟, 王贞佐, 程瑛琨 (10)一种提升认知和记忆能力的保健品组合物及制备方法(ZL201811082873.6) 授权公告日: 20210406 发明人:王迪,曲一笛,胡文继,窦博,逯家辉,滕利荣,孟庆繁,杨雪薇 |